Saturday, March 09, 2013

Radiopharmacy (III)

Development of 99mTc-5-fluorouracil as a potential tumor diagnostic agent.
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The Future of USP Monographs for PET Drugs
Sally Schwarz, Jeffrey Norenberg, Marc Berridge, Stephen Dragotakes, Joseph Hung, Jeanne Link, N. Scott Mason, Steve Mattmuller, Richard A. Nickel, Alan Packard, Justin Paolino, Neil Petry, James Ponto, Timothy M. Quinton, Katherine L. Seifert, Dennis Swanson, Ronald E. Weiner, and Steven Zigler
J Nucl Med 2013 54:472-475 (10.2967/jnumed.112.115089).

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Synthesis and Evaluation of 11C-LY2795050 as a κ-Opioid Receptor Antagonist Radiotracer for PET Imaging
Ming-Qiang Zheng, Nabeel Nabulsi, Su Jin Kim, Giampaolo Tomasi, Shu-fei Lin, Charles Mitch, Steven Quimby, Vanessa Barth, Karen Rash, John Masters, Antonio Navarro, Eric Seest, Evan D. Morris, Richard E. Carson, and Yiyun Huang
J Nucl Med 2013 54:455-463 (10.2967/jnumed.112.109512).

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Phase 0 Microdosing PET Study Using the Human Mini Antibody F16SIP in Head and Neck Cancer Patients
Derrek A. Heuveling, Remco de Bree, Danielle J. Vugts, Marc C. Huisman, Leonardo Giovannoni, Otto S. Hoekstra, C. René Leemans, Dario Neri, and Guus A.M.S. van Dongen
J Nucl Med 2013 54:397-401

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18F-FPEB, a PET Radiopharmaceutical for Quantifying Metabotropic Glutamate 5 Receptors: A First-in-Human Study of Radiochemical Safety, Biokinetics, and Radiation Dosimetry
Dean F. Wong, Rikki Waterhouse, Hiroto Kuwabara, Jongho Kim, James R. Brašić, Wichana Chamroonrat, Michael Stabins, Daniel P. Holt, Robert F. Dannals, Terence G. Hamill, and P. David Mozley
J Nucl Med 2013 54:388-39

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Determination of In Vivo Bmax and Kd for 11C-GR103545, an Agonist PET Tracer for κ-Opioid Receptors: A Study in Nonhuman Primates.
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New Transient Receptor Potential Vanilloid Subfamily Member 1 Positron Emission Tomography Radioligands: Synthesis, Radiolabeling, and Preclinical Evaluation.
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Dopamine D(2/3) occupancy of ziprasidone across a day: a within-subject PET study.
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18F-FPEB, a PET Radiopharmaceutical for Quantifying Metabotropic Glutamate 5 Receptors: A First-in-Human Study of Radiochemical Safety, Biokinetics, and Radiation Dosimetry.
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Non-invasive assessment of hypoxia with 3-[18F]-fluoro-1-(2-nitro-1-imidazolyl)-2-propanol ([18F]-FMISO): a PET study in two experimental models of human glioma.
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High tumor uptake of (64)Cu: Implications for molecular imaging of tumor characteristics with copper-based PET tracers.
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[[11C]choline as a pharmacodynamic marker for docetaxel therapy.]
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Synthesis of radiolabeled protein disulfide isomerase (PDI) inhibitors as new potential PET agents for imaging of the enzyme PDI in neurological disorders and cancer.
Appl Radiat Isot. 2013 Jan 8;74C:61-69.
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Direct comparison of [(18) F]MH.MZ and [(18) F]altanserin for 5-HT(2A) receptor imaging with PET.
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Purification of 2-[(18)F]fluoro-2-deoxy-d-glucose by on-chip solid-phase extraction.
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Development and Characterization of 89Zr-Labeled Panitumumab for Immuno-Positron Emission Tomographic Imaging of the Epidermal Growth Factor Receptor.
Mol Imaging. 2013 Feb 1;12(1):17-27.
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Evaluation of Breast Cancer Resistance Protein Function in Hepatobiliary and Renal Excretion Using PET with 11C-SC-62807
Tadayuki Takashima, Chunyong Wu, Misato Takashima-Hirano, Yumiko Katayama, Yasuhiro Wada, Masaaki Suzuki, Hiroyuki Kusuhara, Yuichi Sugiyama, and Yasuyoshi Watanabe
J Nucl Med 2013 54:267-276 

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Development and Evaluation of 18F-TTCO-Cys40-Exendin-4: A PET Probe for Imaging Transplanted Islets
Zhanhong Wu, Shuanglong Liu, Matthew Hassink, Indu Nair, Ryan Park, Lin Li, Ivan Todorov, Joseph M. Fox, Zibo Li, John E. Shively, Peter S. Conti, and Fouad Kandeel
J Nucl Med 2013 54:244-251

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Orthogonal synthesis of a heterodimeric ligand for the development of the Gd(III)-Ga(III) ditopic complex as a potential pH-sensitive MRI/PET probe.
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Analysis of [11C]methyl-candesartan kinetics in the rat kidney for the assessment of angiotensin II type 1 receptor density in vivo with PET
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Automated Radiosynthesis of [18F]ML-10, a PET Radiotracer Dedicated to Apoptosis Imaging, on a TRACERLab FX-FN Module
Franck Sobrio, Marie Médoc, Ludovic Martial, Jérôme Delamare & Louisa Barré
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Kit like" (18)F labeling method for synthesis of RGD peptide-based PET probes.
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Radiosynthesis and initial evaluation of 18F labeled nanocarrier composed of poly(L-lactic acid)-block-poly(sarcosine) amphiphilic polydepsipeptide
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Fibrin-Targeted PET Probes for the Detection of Thrombus.
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Review on Production of 89Zr in a Medical Cyclotron for PET Radiopharmaceuticals.
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Positron Emission Tomography Imaging of Tumor Angiogenesis with a (61/64)Cu-Labeled F(ab')(2) Antibody Fragment.
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Characterization of fast-decaying PET radiotracers solely through LC-MS/MS of constituent radioactive and carrier isotopologues.
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Convergent synthesis and evaluation of (18)F-labeled azulenic COX2 probes for cancer imaging.
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Comparison of FASTlab 18F-FDG Production Using Phosphate and Citrate Buffer Cassettes
James Z. Long, Mark S. Jacobson, and Joseph C. Hung
J. Nucl. Med. Technol. published 14 January 2013
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Preclinical Safety Assessment of the 5-HT(2A) Receptor Agonist PET Radioligand [ (11)C]Cimbi-36.
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Development of (18)F-Labeled Picolinamide Probes for PET Imaging of Malignant Melanoma.
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Synthesis and evaluation of new radioligands [(11)C]A-833834 and [(11)C]A-752274 for positron-emission tomography of α7-nicotinic acetylcholine receptors.
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Potent and selective Tariquidar bioisosters as potential PET radiotracers for imaging P-gp
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Fully automated synthesis of 4-[18F]fluorobenzylamine based on borohydride/NiCl2 reduction
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Human biodistribution and dosimetry of 18F-JNJ42259152, a radioligand for phosphodiesterase 10A imaging
Koen Van Laere, Rawaha U. Ahmad, Hendra Hudyana, Sofie Celen, Kristof Dubois, Mark E. Schmidt, Guy Bormans & Michel Koole

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Evaluation in vitro and in animals of a new 11C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain
Paolo Zanotti-Fregonara, Vanessa N. Barth, Jeih-San Liow, Sami S. Zoghbi, David T. Clark, Emily Rhoads, Edward Siuda, Beverly A. Heinz, Eric Nisenbaum, Bruce Dressman, Elizabeth Joshi, Debra Luffer-Atlas, Matthew J. Fisher, John J. Masters, Nancy Goebl, Steven L. Kuklish, Cheryl Morse, Johannes Tauscher, Victor W. Pike & Robert B. Innis
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In vivo characterization of 68Ga-NOTA-VEGF121 for the imaging of VEGF receptor expression in U87MG tumor xenograft models
Choong Mo Kang, Sung-Min Kim, Hyun-Jung Koo, Min Su Yim, Kyung-Han Lee, Eun Kyoung Ryu & Yearn Seong Choe

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RGD Peptide–Conjugated Multimodal NaGdF4:Yb3+/Er3+ Nanophosphors for Upconversion Luminescence, MR, and PET Imaging of Tumor Angiogenesis
Junghan Lee, Tae Sup Lee, Jiyoung Ryu, Sukmin Hong, Moonsik Kang, Kangbin Im, Joo Hyun Kang, Sang Moo Lim, Sun Park, and Rita Song
J Nucl Med 2013 54:96-103

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Radiosynthesis and Preclinical Evaluation of 3'-Aza-2'-[18F]Fluorofolic Acid - A Novel PET Radiotracer for Folate Receptor Targeting.
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The development of potential new fluorine-18 labelled radiotracers for imaging the GABA(A) receptor.
Bioorg Med Chem Lett. 2012 Nov 28. 
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Radiolabelling and preliminary evaluation of (68)Ga-tetrapyrrole derivatives as potential tracers for PET.
Nucl Med Biol. 2012 Dec 19
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Evaluation of [(18)F]Nifene biodistribution and dosimetry based on whole-body PET imaging of mice.
Nucl Med Biol. 2012 Dec 19. pii: S0969-8051(12)00293-4
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The Future of USP Monographs for PET Drugs.
J Nucl Med. 2012 Dec 21. 
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Evaluation of an integrin α(v)β(6)-specific peptide labeled with [(18)F]fluorine by copper-free, strain-promoted click chemistry.
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Development and automation of a novel NET-PET tracer: [(11)C]Me@APPI.
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Preclinical and the first clinical studies on [(11)C]ITMM for mapping metabotropic glutamate receptor subtype 1 by positron emission tomography.
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Investigation of Zr(iv) and (89)Zr(iv) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging.
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Kinetic analysis of the metabotropic glutamate subtype 5 tracer [(18)F]FPEB in bolus and bolus-plus-constant-infusion studies in humans.
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Past, present and future of (68)Ge/(68)Ga generators.
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Fluorinated quinazolinones as potential radiotracers for imaging kinesin spindle protein expression.
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Graphic plot analysis for estimating binding potential of translocator protein (TSPO) in positron emission tomography studies with [(18)F]FEDAA1106.
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The Effect of the Prosthetic Group on the Pharmacologic Properties of 18F-labeled Rhodamine B, a Potential Myocardial Perfusion Agent for PET.
--Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity.
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Biodistribution, Tumor Detection, and Radiation Dosimetry of 18F-DCFBC, a Low-Molecular-Weight Inhibitor of Prostate-Specific Membrane Antigen, in Patients with Metastatic Prostate Cancer.
SY Cho, KL Gage, RC Mease, S Senthamizhchelvan, DP Holt, A Jeffrey-Kwanisai, CJ Endres, RF Dannals, G Sgouros, M Lodge, MA Eisenberger, R Rodriguez, MA Carducci, C Rojas, BS Slusher, AP Kozikowski, and MG Pomper
J Nucl Med. 2012; 53: 1883

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AZD5213: a novel histamine H3 receptor antagonist permitting high daytime and low nocturnal H3 receptor occupancy, a PET study in human subjects.
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Discovery of novel α(1)-adrenoceptor ligands based on the antipsychotic sertindole suitable for labeling as PET ligands.
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Synthesis, in vitro and in vivo characterization of two novel (68)Ga-labelled 5-nitroimidazole derivatives as potential agents for imaging hypoxia.
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RGD Peptide-Conjugated Multimodal NaGdF4:Yb3+/Er3+ Nanophosphors for Upconversion
Luminescence, MR, and PET Imaging of Tumor Angiogenesis.
J Nucl Med. 2012.
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Radiopharmaceuticals in Nuclear Pharmacy and Nuclear Medicine.
J Nucl Med. 2012.
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The untapped potential of Gallium 68-PET: The next wave of (68)Ga-agents.
Appl Radiat Isot. 2012 Oct 29. pii: S0969-8043(12)00537.
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(4S)-4-(3-18F-Fluoropropyl)-L-Glutamate for Imaging of xC Transporter Activity in
Hepatocellular Carcinoma Using PET: Preclinical and Exploratory Clinical Studies.
J Nucl Med. 2012.
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Evaluation of [(18)F]MK-0911, a Positron Emission Tomography (PET) Tracer for Opioid Receptor-Like 1 (ORL1), in Rhesus Monkey and Human.
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An in vivo molecular imaging probe (18)F-Annexin B1 for apoptosis detection by PET/CT: preparation and preliminary evaluation.
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A novel sulfonated prosthetic group for [(18)F]-radiolabelling and imparting water solubility of biomolecules 
and cyanine fluorophores.
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PET imaging of the brain serotonin transporters (SERT) with N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) in humans: a preliminary study
Wen-Sheng Huang, San-Yuan Huang, Pei-Shen Ho, Kuo-Hsing Ma, Ya-Yao Huang, Chin-Bin Yeh, Ren-Syuan Liu, Cheng-Yi Cheng & Chyng-Yann Shiue

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Positron emission tomography (PET) imaging with (18)F-based radiotracers.
Am J Nucl Med Mol Imaging. 2012;2(1):55-76
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The clinical use of PET with (11)C-acetate.
Am J Nucl Med Mol Imaging. 2012;2(1):33-47.
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Synthesis, radiolabelling and in vitro and in vivo evaluation of a novel fluorinated ABP688 derivative for the PET imaging of metabotropic glutamate receptor subtype 5.
Am J Nucl Med Mol Imaging. 2012;2(1):14-28
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A Unique Matched Quadruplet of Terbium Radioisotopes for PET and SPECT and for α- and β-Radionuclide Therapy: An In Vivo Proof-of-Concept Study with a New Receptor-Targeted Folate Derivative
Cristina Müller, Konstantin Zhernosekov, Ulli Köster, Karl Johnston, Holger Dorrer, Alexander Hohn, Nico T. van der Walt, Andreas Türler, and Roger Schibli
J Nucl Med 2012 53:1951-1959

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Development of N-[4-[6-(Isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methyl-4-[(11)C]methylbenzamide for Positron Emission Tomography Imaging of Metabotropic Glutamate 1 Receptor in Monkey Brain.
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Identification of PET radiometabolites by cytochrome P450, UHPLC/Q-ToF-MS and fast radio-LC: applied to the PET radioligands [(11)C]flumazenil, [ (18)F]FE-PE2I, and [ (11)C]PBR28.
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Human biodistribution and dosimetry of (18)F-JNJ42259152, a radioligand for phosphodiesterase 10A imaging.
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Radiolabeling of two 11C-labeled formylating agents and their application in the preparation of [11C]benzimidazole
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Synthesis and evaluation of (68)Ga-labeled DOTA-2-deoxy-D-glucosamine as a potential radiotracer in μPET imaging.
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Radiolabeling of two 11C-labeled formylating agents and their application in the preparation of [11C]benzimidazole
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Longitudinal PET Imaging of Doxorubicin-Induced Cell Death with 18F-Annexin V
Shuo Hu, Dale O. Kiesewetter, Lei Zhu, Ning Guo, Haokao Gao, Gang Liu, Naoki Hida, Lixin Lang, Gang Niu & Xiaoyuan Chen

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New Frontiers in the Design and Synthesis of Imaging Probes for PET Oncology: Current Challenges and Future Directions
Graham Smith, Laurence Carroll & Eric O. Aboagye

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Compensation for cranial spill-in into the cerebellum improves quantitation of
striatal dopamine D(2)/(3) receptors in rats with prolonged [(1)(8)F]-DMFP
infusions.
Synapse. 2012;66:705-13
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Evaluation in vitro and in animals of a new (11)C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain.
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Mapping Biological Behaviors by Application of Longer-Lived Positron Emitting Radionuclides.
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Rapid metabolite analysis of positron emission tomography radioligands by direct plasma injection combining micellar cleanup with high submicellar liquid chromatography with radiometric detection.
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[(68)Ga]NS(3)-RGD and [(68)Ga] Oxo-DO3A-RGD for imaging α(v)β(3) integrin expression: synthesis, evaluation, and comparison.
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Current status and future needs for standards of radionuclides used in positron
emission tomography.
Appl Radiat Isot. 2012 Sep 23. pii: S0969-8043(12)00500.
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PET and SPECT tracers for mGluR glutamate receptors.
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Nature or Nurture? Determining the Heritability of Human Striatal Dopamine Function: an [18F]-DOPA PET Study.
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Synthesis of an activated phosphonated bifunctional chelate with potential for PET imaging and radiotherapy.
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Current status and future needs for standards of radionuclides used in positron emission tomography.
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Nickel-Mediated Oxidative Fluorination for PET with Aqueous [(18)F] Fluoride.
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Rapid biochemical synthesis of (11)C-labeled single chain variable fragment antibody for immuno-PET by cell-free protein synthesis.
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Metabolism and Quantification of [18F]DPA-714, a New TSPO Positron Emission Tomography Radioligand.
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64Cu-p-NH2-Bn-DOTA-hu14.18K322A, a PET Radiotracer Targeting Neuroblastoma and Melanoma.
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(44)Sc-DOTA-BN[2-14]NH(2) in comparison to (68)Ga-DOTA-BN[2-14]NH(2) in
pre-clinical investigation. Is (44)Sc a potential radionuclide for PET?
Appl Radiat Isot. 2012;70:2669-2676.
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Optimization of the solid-phase synthesis of [(18)F] radiolabeled peptides for
positron emission tomography.
Appl Radiat Isot. 2012;70:2720-2729.
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Fluorine-18 Radiolabeling and Radiopharmacological Characterization of a Benzodioxolylpyrimidine-based Radiotracer Targeting the Receptor Tyrosine Kinase EphB4.
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Imaging of genetically engineered T cells by PET using gold nanoparticles complexed to Copper-64.
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Design and Synthesis of an 18F-Labeled Version of Phenylethyl Orvinol ([18F]FE-PEO) for PET-Imaging of Opioid Receptors.
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Validation of a Paper Chromatographic Methodology as an Alternative for Determination of the Radiochemical Purity of Na18F.
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Evolution of Bombesin Conjugates for Targeted PET Imaging of Tumors.
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[(18)F](R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one: Introduction of N(3)-phenylpyrazinones as potential CRF-R1 PET imaging agents.
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Radiolabelling of 1,4-disubstituted 3-[(18)F]fluoropiperidines and its application to new radiotracers for NR2B NMDA receptor visualization.

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Annotating MYC status with (89)Zr-transferrin imaging.
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A pilot study for the early assessment of the effects of BMS-754807 plus gefitinib in an H292 tumor model by [(18)F]fluorothymidine-positron emission tomography.
Invest New Drugs. 2012 Sep 18
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Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with (18)F-FAHA.
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Hypoxia Imaging of Uterine Cervix Carcinoma With 18F-FETNIM PET/CT.
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Pharmacokinetic Properties of Intravitreal I-124-Aflibercept in a Rabbit Model Using PET/CT.
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Synthesis, Evaluation and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging.
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A pilot study for the early assessment of the effects of BMS-754807 plus gefitinib in an H292 tumor model by [(18)F]fluorothymidine-positron emission tomography.
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Structure–Activity Relationship and Preclinical Evaluation of Carbon-11-Labeled Ammonium Salts as PET–Myocardial Perfusion Imaging Agents
Ohad Ilovich, Galith Abourbeh, Moshe Bocher, Nanette Freedman, Hana Billauer, Sharon Dotan, Haim D. Danenberg & Eyal Mishani

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Fully Automated Production of 11C-Doxepin for PET Imaging Histamine H1 Receptor
Hancheng Cai, Thomas J. Mangner, Otto Muzik, Xin Lu, Pulak K. Chakraborty, Diane C. Chugani & Harry T. Chugani

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Synthesis and preclinical evaluation of the radiolabeled P-glycoprotein inhibitor [(11)C]MC113.
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PET Imaging of Lung Inflammation with [(18)F]FEDAC, a Radioligand for Translocator Protein (18 kDa).
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The Practicality of Nanoceria-PAN-Based (68)Ge/(68)Ga Generator Toward Preparation of (68)Ga-Labeled Cyclic RGD Dimer as a Potential PET Radiotracer for Tumor Imaging.
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Exploratory Clinical Trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for Imaging xC Transporter Using Positron Emission Tomography in Patients with Non–Small Cell Lung or Breast Cancer
Sora Baek, Chang-Min Choi, Sei Hyun Ahn, Jong Won Lee, Gyungyub Gong, Jin-Sook Ryu, Seung Jun Oh, Claudia Bacher-Stier, Lüder Fels, Norman Koglin, Christina Hultsch, Christoph A. Schatz, Ludger M. Dinkelborg, Erik S. Mittra, Sanjiv S. Gambhir, and Dae Hyuk Moon
Clin. Cancer Res. published 10 September 2012
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New Frontiers in the Design and Synthesis of Imaging Probes for PET Oncology: Current Challenges and Future Directions.
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Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors.
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Comparative Evaluation of 18F-Labeled Glutamic Acid and Glutamine as Tumor Metabolic Imaging Agents.
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Optimized In Vivo Detection of Dopamine Release Using 18F-Fallypride PET.
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Synthesis and characterization of two PET radioligands for the metabotropic glutamate 1 (mGlu1) receptor.
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[(18)F]FE@SNAP-A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approaches.
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New PET imaging agents in the management of solid cancers.
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[(11)C]Rhodamine-123: Synthesis and biodistribution in rodents.
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Radiation Dosimetry and Biodistribution of the Hypoxia Tracer (18)F-EF5 in Oncologic Patients.
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Single-step radiosynthesis and in vivo evaluation of a novel fluorine-18 labeled hippurate for use as a PET renal agent.
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Whole Body Biodistribution and Radiation Dosimetry in Humans of a New PET Ligand, [(18)F]-FEPPA, to Image Translocator Protein (18 kDa).
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Preclinical evaluation and quantification of [18F]MK-9470 as a radioligand for PET imaging of the type 1 cannabinoid receptor in rat brain
Cindy Casteels, Michel Koole, Sofie Celen, Guy Bormans & Koen Van Laere

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PET Imaging of alpha4beta2* Nicotinic Acetylcholine Receptors: Qualitative
Analysis of 18F-Nifene Kinetics in the Nonhuman Primate.
J Nucl Med. 2012.

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The Synthesis and In Vivo Pharmacokinetics of Fluorinated Arachidonic Acid: Implications for Imaging Neuroinflammation.

18F-HX4 hypoxia imaging with PET/CT in head and neck cancer: a comparison with 18F-FMISO.

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Synthesis and Evaluation of Novel a-Fluorinated (E)-3-((6-Methylpyridin-2-yl)ethynyl)cyclohex-2-enone-O-methyl oxime (ABP688) Derivatives as Metabotropic Glutamate Receptor Subtype 5 PET Radiotracers.
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Aquaporin-4 Positron Emission Tomography Imaging of the Human Brain: First Report.
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The role of positron emission tomography using carbon-11 and fluorine-18 choline in tumors other than prostate cancer: a systematic review
Giorgio Treglia, Elisabetta Giovannini, Davide Di Franco, Maria Lucia Calcagni, Vittoria Rufini, Maria Picchio & Alessandro Giordano

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PET imaging of liposomes labeled with an [18F]-fluorocholesteryl ether probe prepared by automated radiosynthesis.
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An improved strategy for the synthesis of [18F]-labeled arabinofuranosyl nucleosides
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[18F]Fluoride labelling of macromolecules in aqueous conditions: silicon and boroaryl-based [18F]fluorine acceptors, [18F]FDG conjugation and Al18F chelation
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Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[11 C]methylpiperidin-2-yl} (phenyl)methyl]3- trifluoromethyl-benzamide ([11 C]N-methyl- SSR504734) as a PET radioligand for glycine transporter 1.
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Novel radiolabeled peptides for breast and prostate tumor PET imaging: 64Cu/ and 68Ga/NOTA-PEG-[D-Tyr6,βAla11,


Thi13,Nle14]BBN(6-14).
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F-18 Labeling Protocol of Peptides Based on Chemically Orthogonal Strain-Promoted Cycloaddition under Physiologically Friendly Reaction Condition.
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Highly efficient click labeling using 2-[(18)F]fluoroethyl azide and synthesis of an (18)FN-hydroxysuccinimide ester as conjugation agent.
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Positron emission tomography radiopharmaceutical studies in humans: a guide to regulations for academic researchers.
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Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: A [11C] FLB-457 and PET study.
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PET imaging with small-molecule tyrosine kinase inhibitors: TKI-PET.
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Description of High Purity and High Specific Activity of [11C]Choline Synthesis Using TRACERlab FXc Module, and Detailed Report of Quality Controls.
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Preclinical characterization of (18)F-MAA, a novel PET surrogate of (99m)Tc-MAA.
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Automated Radiosynthesis of [(18)F]ML-10, a PET Radiotracer Dedicated to Apoptosis Imaging, on a TRACERLab FX-FN Module.
Mol Imaging Biol. 2012 Jul 3. 
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TH-E-BRA-04: Feasibility of Mapping Transient Tumor Hypoxia Using in Situ Activation PET Imaging: A Simulation Study.
Med Phys. 2012 Jun;39(6):4012
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Radiosynthesis of a (68)Ga labeled matrix metalloproteinase inhibitor as a potential probe for PET imaging.
Appl Radiat Isot. 2012 Apr 25;70(8):1723-1728.
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Development of new carbon-11 labelled radiotracers for imaging GABA(A)- and GABA(B)-benzodiazepine receptors.
Bioorg Med Chem. 2012 May 24. 
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Imaging of VMAT2 binding sites in the brain by (18)F-AV-133: The effect of a pseudo-carrier.
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Synthesis and biological evaluation of two agents for imaging estrogen receptor β by positron emission tomography: challenges in PET imaging of a low abundance target.
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In Vitro and In Vivo Evaluation of [(18)F]F-GAZ, a Novel Oxygen-Mimetic Azomycin-Glucose Conjugate, for Imaging Hypoxic Tumor.
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Quantification of Dopamine Transporter in Human Brain Using PET with 18F-FE-PE2I
Takeshi Sasaki, Hiroshi Ito, Yasuyuki Kimura, Ryosuke Arakawa, Harumasa Takano, Chie Seki, Fumitoshi Kodaka, Saori Fujie, Keisuke Takahata, Tsuyoshi Nogami, Masayuki Suzuki, Hironobu Fujiwara, Hidehiko Takahashi, Ryuji Nakao, Toshimitsu Fukumura, Andrea Varrone, Christer Halldin, Toru Nishikawa, and Tetsuya Suhara
J Nucl Med 2012;53 1065-1073
http://jnm.snmjournals.org/



cgi/content/abstract/53/7/1065
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Transport of 3-Fluoro-L-α-Methyl-Tyrosine by Tumor-Upregulated L-Type Amino Acid Transporter 1: A Cause of the Tumor Uptake in PET.
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Copper-62 Labeled ReCCMSH Peptide Analogs For Melanoma PET Imaging.